Commentary from Brian Loveridge, MD; Detailed scientific exploration of how impaired insulin production leads to a breakdown in carbohydrate metabolism. In pre-diabetes, the body tries to overcome progressive insulin resistance by producing higher levels of insulin. Unfortunately, this creates a “toxic” environment for these receptors. With increasing insulin “resistance,” a patient goes from impaired glucose metabolism to type 2 diabetes. We aim to restore the natural physiology toward improved glycemic control.